Use of HER2 dimerization inhibitor pertuzumab and articles of manufacture containing pertuzumab

摘要

This application describes the use of pertuzumab, a first-in-class HER2 dimerization inhibitor, and articles of manufacture comprising it. In particular, the present application relates to a method for extending progression-free survival in a population of HER2-positive breast cancer patients; for combining two HER2 antibodies to treat HER2-positive cancer cancer without increasing cardiotoxicity A method for treating early HER2-positive breast cancer; a method for treating HER2-positive cancer by co-administering a mixture of pertuzumab and trastuzumab from the same intravenous drip bag; for treating HER2-positive metastatic gastric cancer A method for treating HER2-positive breast cancer with pertuzumab, trastuzumab and vinorelbine; a method for treating HER2-positive breast cancer with pertuzumab, trastuzumab and an aromatase inhibitor; and low HER3 ovarian cancer, primary peritoneal cancer or fallopian tube A method for treating cancer is described. The application also provides a product comprising a vial comprising pertuzumab and a package insert providing safety and / or efficacy data; a method for producing said product; and the safe and effective use of pertuzumab associated therewith. Describe how to ensure. In addition, this application describes an intravenous (IV) bag containing a stable mixture of pertuzumab and trastuzumab suitable for administration to cancer patients.