N- oxycarbonyl - (2S) - oxycarbonyl - (5S) - method of manufacturing a phosphonyl pyrrolidine derivative

摘要

PROBLEM TO BE SOLVED: To provide a new method for preferentially producing an N-oxycarbonyl-(2S)-oxycarbonyl-(5S)-phosphonylpyrrolidine derivative.;SOLUTION: An N-oxycarbonyl-α-alkoxy-L-proline derivative represented by formula (I) (wherein R¹ is a 1-5C alkyl group; R³ is a 1-5C alkyl group, a phenyl group or a benzyl group; and R⁴ is a methyl group or an ethyl group) is caused to react with a phosphorous acid ester derivative represented by formula (II) (wherein R² is a 1-5C alkyl group, a phenyl group or a benzyl group) in the presence of a Lewis acid.;COPYRIGHT: (C)2011,JPO&INPIT