Selectively target drug release carrier comprising a carbohydrate carrying dendrimer

摘要

PROBLEM TO BE SOLVED: To provide a support which delivers a drug to a target site and can release the drug at the site, and to provide a medicine including the drug on the support.;SOLUTION: There is provided a drug-releasing support including a polymer micelle structure formed of a sugar chain supported dendrimer represented by formula (I), wherein E¹ represents any one of carbon, silicon and germanium, E² represents either one of silicon and germanium, R¹ represents a hydrocarbon group which may contain a hetero atom, and may form a ring including E¹, R² represents a hydrocarbon group or a hydrocarbon chain which may have a ring, R³, R⁴ and R⁵ each represents a hydrocarbon chain which may contain oxygen, nitrogen or a carbonyl group, an ether group, or an amide group, Y represents a sugar chain residue, l is an integer of 0 to 2, m is an integer of 0 to 2, k is a number of 0 or 1, and when k is 0, 3-m is 1.;COPYRIGHT: (C)2011,JPO&INPIT