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how to induce hepatic differentiation from induced liver stem cells and induced liver progenitor cells

机译:如何从诱导的肝干细胞和诱导的肝祖细胞诱导肝分化

摘要

The present invention, embryonic stem cells, induced pluripotent stem cells or induced liver stem cells, from a stem cell selected from, it is to present a method in which the liver differentiation. More specifically, the present invention makes embryonic stem cells, induced pluripotent stem cells, or induce stem cell selected from the hepatic stem cells, the step of culturing 1-4 weeks in the presence of TGF- inhibitors It makes it way to the embryonic stem cells, induced pluripotent stem cells, or induce stem cell selected from the hepatic stem cells to hepatic differentiation.
机译:本发明从选自干细胞的胚胎干细胞,诱导的多能干细胞或诱导的肝干细胞中,提出一种肝分化的方法。更具体地,本发明制备胚胎干细胞,诱导的多能干细胞或诱导选自肝干细胞的干细胞,在存在TGF-β抑制剂的情况下培养1-4周的步骤使其进入胚胎干。细胞,诱导多能干细胞或诱导选自肝干细胞的干细胞向肝分化。

著录项

  • 公开/公告号JPWO2013018851A1

    专利类型

  • 公开/公告日2015-03-05

    原文格式PDF

  • 申请/专利号JP20130526951

  • 发明设计人 石川 哲也;

    申请日2012-08-02

  • 分类号C12N5/071;C12N5/0735;

  • 国家 JP

  • 入库时间 2022-08-21 15:27:51

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