The present invention, embryonic stem cells, induced pluripotent stem cells or induced liver stem cells, from a stem cell selected from, it is to present a method in which the liver differentiation. More specifically, the present invention makes embryonic stem cells, induced pluripotent stem cells, or induce stem cell selected from the hepatic stem cells, the step of culturing 1-4 weeks in the presence of TGF- inhibitors It makes it way to the embryonic stem cells, induced pluripotent stem cells, or induce stem cell selected from the hepatic stem cells to hepatic differentiation.
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