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Method for Inducing Immune Tolerance Using Non-Proliferative Polymer-Modified Allogeneic Leukocytes
Method for Inducing Immune Tolerance Using Non-Proliferative Polymer-Modified Allogeneic Leukocytes
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机译:用非增殖性聚合物修饰的同种异体白细胞诱导免疫耐受的方法
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摘要
This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population. The non-proliferative allogeneic leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition with the latter leukocyte population. Cellular-based preparations and processes for achieving cellular therapy are also provided.
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