Nucleic acid sequence, carrier of mitochondrial tricarboxu00edlico acid, method for the production of acid itacu00f4nico, host cell and uses of a protein and a combination of a protein with the enzyme CAD, and / or a carrier MFS

摘要

The invention relates to a nucleic acid sequence encoding an Aspergillus mitochondrial tricarboxylic acid transporterthat can be used in the production of itaconic acid in micro-organisms. Preferably said transporter protein is the protein encoded by the nucleic acid which is located on a chromosome segment of A. terreus that also harbours other genes involved in the itaconic acid biosynthesis and the lovastatin biosynthesis. Also, vectors, hosts and transformed micro-organisms are part of the invention.