Resistance to fracture an oral pharmaceutical dosage form comprising a pharmacologically active ingredient opioid antagonist and / or a means, is disgusting, polyalkylene oxide and anionic polymers

摘要

The invention relates to a pharmaceutical dosage form for oral administration, which has a tensile strength of at least 300 N and which contains (I) a pharmacologically active ingredient; (Ii) an opioid antagonist and / or aversion agent; (Iii) a polyalkylene oxide that has an average molecular weight of at least 200,000 g / mol; and (a) which contains (IV) an anionic polymer and / or (b) has storage stability at 40 ° C. for at least 3 months.