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Pharmaceutical compositions comprising a glucocorticoid or glucocorticoid derivative encapsulated in a liposome
Pharmaceutical compositions comprising a glucocorticoid or glucocorticoid derivative encapsulated in a liposome
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机译:包含包裹在脂质体中的糖皮质激素或糖皮质激素衍生物的药物组合物
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摘要
The present invention provides pharmaceutical compositions comprising a glucocorticoid or glucocorticoid derivative stably encapsulated in a liposome. The glucocorticoid or glucocorticoid derivative is selected from an amphipathic weak base glucocorticoid or glucocorticoid derivative having a pKa equal or below 11 and a logD at pH 7 in the range between -2.5 and 1.5; or an amphipathic weak acid GC or GC derivative having a pKa above 3.5 and a logD at pH 7 in the range between -2.5 and 1.5. The therapeutic effect of the pharmaceutical composition of the invention was exhibited in vivo with appropriate models of multiple sclerosis and cancer.
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