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Method for synthesizing n-5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yln-methyl-2-4-(2-pyridinyl)phenylacetamide and the mesylate monohydrate salt thereof
Method for synthesizing n-5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yln-methyl-2-4-(2-pyridinyl)phenylacetamide and the mesylate monohydrate salt thereof
The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.
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