2-2-(HYDROXYACETYL)AMINO-4-PYRIDINYLMETHYLTHIO-N-4-(TRIFLUOROMETHOXY)PHENYL-3-PYRIDINECARBOXAMIDE BENZENESULFONATE CRYSTAL OF SAME CRYSTAL POLYMORPH THEREOF AND METHODS FOR PRODUCTION THEREOF

摘要

In the course of developing 2-[[[2 - [(hydroxyacetyl) amino]- 4 -pyridinyl] methyl] thio]- N -[4 -(trifluoromethoxy) phenyl]- 3 -pyridinecarboxamide(compound A)  there are the multiple problems: 1) compound A or its salt is difficult to be recrystallized  the storage stability largely differs depending on the kind of the salt  and it is very difficult to obtain a salt of compound A having excellent storage stability; 2) in a crystallization process of compound A  it is very difficult to control a crystal polymorph  and 3) compound A (free body) causes mineral deposition in the stomach when it is orally administered repeatedly.