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MULTILAYER BIODEGRADABLE MICROPARTICLES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS.
MULTILAYER BIODEGRADABLE MICROPARTICLES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS.
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机译:多层生物可降解微粒,可持久释放治疗剂。
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摘要
Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition; (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the second composition; and (c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer.
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