Compositions and methods for separating, characterizing and administering soluble selenoglycoproteins

摘要

Discloses a method for preparation of soluble selenoglycoproteins comprising: a) providing selenium enriched yeast; b) exposing the selenium enriched yeast to acidic conditions followed by centrifugation to generate (I) a pellet comprising acid insoluble material; and (ii) a liquid phase comprising the extract of selenium enriched yeast soluble under the acidic conditions; c) precipitating selenoglycoproteins from the liquid phase comprising the extract of selenium enriched yeast soluble under the acidic conditions via raising the pH level of the liquid phase; and d) separating the precipitated selenoglycoproteins from the liquid phase.