It refers to polyamide, which includes the first domain name selected from the CTLA4, PD-1 and BTLA groups, which is a kind of polyamide, associated with a negative Senal; the second domain name, which is a kind of polyamide, selected from the CD28 group,ICOS, this is a positive signal. The fusion protein also includes a transmembrane domain. Thus, the invention includes a change receiver capable of converting a negative signal into a positive signal to promote an immune response.
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