symmetrical polar kinase inhibitors hill antitumor activity

摘要

The invention relates to symmetrical polar compounds of bispyridinium, bisquinuclidinium and bisquinolinium with a linker derived from 1,2-bis(p-tolyloxy)ethane, which are inhibitors of choline kinase. The invention also relates to the synthesis thereof and to the use of same as anti-tumour medicaments.