COMPOSITIONS, MEDICAL DEVICES AND GRAFTS COMPRISING CTP SYNTHASE 1 INHIBITORS AND THEIR USE FOR REDUCING NEOINTIMA FORMATION

摘要

Compositions, devices, grafts and uses thereof for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Reduction of neointima formation, acceleration of re-endothelialization, and reduction of restenosis in a subject using the compositions, devices, and grafts are also disclosed.