Anti-ILT7 Antibody

摘要

#$%^&*AU2014265023A120141204.pdf#####Abstract An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The antibody of the invention has a high specificity which allows immunological distinction between other ILT family molecules and ILT7. The anti-ILT7 antibody of the invention bound to IPC and inhibited the activity thereof. With the anti:-ILT7 antibody of the invention, the IPC activity can be inhibited and an interferon-related disease can be treated or prevented. ILT7 expression is maintained even in IPC in the presence of IFN. Thereforer an inhibitory action of IPC activity by the anti-ILT7 antibody can be expected even in an autoimmune. disease patient with an increased production of IFNa. 83