首页> 外国专利> USE OF PROPYLPARABEN AS NEUROPROTECTIVE AGENT TO ATTENUATE BRAIN DAMAGE PRODUCED BY STATUS EPILEPTICUS

USE OF PROPYLPARABEN AS NEUROPROTECTIVE AGENT TO ATTENUATE BRAIN DAMAGE PRODUCED BY STATUS EPILEPTICUS

机译：使用丙基对乙酰氨基苯甲酸酯作为神经保护剂来减轻癫痫持续状态引起的脑损伤

页面导航

摘要
著录项
相似文献

摘要

The present invention describes the use of propylparaben, a widely known antimicrobial, for decreasing neuronal injury induced by Status epilepticus. An objective of the invention is the administration of propylparaben immediately after the occurrence of Status epilepticus to prevent neuronal injury and the possible development of epileptogenesis, as well the neurocognitive disorders associated with this condition.

机译：本发明描述了对羟基苯甲酸丙酯，一种广为人知的抗微生物剂，用于减少由癫痫持续状态引起的神经元损伤的用途。本发明的一个目的是在癫痫持续状态发生后立即给予对羟基苯甲酸丙酯，以预防神经元损伤和癫痫发生的可能发展，以及与这种情况有关的神经认知障碍。 展开▼

著录项

公开/公告号WO2015049608A1

专利类型

公开/公告日2015-04-09

原文格式PDF

申请/专利权人 CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITÉCNICO NACIONAL;CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS;UNIVERSIDAD NACIONAL DE LA PLATA;
展开▼

申请/专利号WO2014IB64484

发明设计人 ROCHA ARRIETA LUISA LILIA;SANTANA GÓMEZ CÉSAR EMMANUEL;BRUNO BLANCH LUIS;OROZCO SUÁREZ SANDRA ADELA;TALEVI ALAN;LETICIA BELLERA CAROLINA;
展开▼

申请日2014-09-13

分类号C07C69/84;A61K31/235;A61P25/08;

国家 WO

入库时间 2022-08-21 15:07:18

相似文献

专利

外文文献

中文文献

1. 百里醌在制备防治癫痫持续状态脑损伤的药物中的应用 [P] . 中国专利： CN105616392A . 2016-06-01

2. 一种用于CO中毒迟发脑损伤的神经保护剂及其用途 [P] . 中国专利： CN109260216B . 2021.05.07

3. USE OF PROPYLPARABEN AS NEUROPROTECTIVE AGENT TO ATTENUATE BRAIN DAMAGE PRODUCED BY STATUS EPILEPTICUS. [P] . MX354615B . 2018-03-08

机译：使用丙基对羟基苯甲酸酯作为神经保护剂来减轻癫痫持续状态所造成的脑损伤。

4. USE OF PROPYLPARABEN AS NEUROPROTECTIVE AGENT TO ATTENUATE BRAIN DAMAGE PRODUCED BY STATUS EPILEPTICUS. [P] . MX2013011437A . 2015-04-10

机译：使用丙基对羟基苯甲酸酯作为神经保护剂来减轻癫痫持续状态所造成的脑损伤。

5. compound or a salt thereof, prodrug, drug, fatty acid amide hydrolase inhibitor, use of the compound or prodrug, fatty acid amide hydrolase inhibition methods in a mammal, brain cell protection and / or neural cells in a mammal to prevent or treat cerebrovascular disorders, head injury or spinal cord damage in a mammal, to prevent or treat disease, to protect brain cells and / or neural cells in a mammal, of Measuring a Fatty Acid Amide Hydrolase Activity and Preventing or Treating Sleep Disorders in a Mammal, Brain-Neuroprotective and Therapeutic or Prophylactic Agents, Kit, and Process for Producing a Compound [P] . BRPI0517753A . 2008-10-21

机译：化合物或其盐，前药，药物，脂肪酸酰胺水解酶抑制剂，在哺乳动物中使用该化合物或前药，脂肪酸酰胺水解酶抑制方法，在哺乳动物中保护脑细胞和/或神经细胞以预防或治疗脑血管疾病，以预防或治疗哺乳动物的疾病，保护哺乳动物的脑细胞和/或神经细胞，预防或治疗疾病，保护脂肪酸酰胺水解酶的活性并预防或治疗哺乳动物的脑部睡眠障碍-神经保护和治疗或预防剂，试剂盒和生产化合物的方法

1. Cinnamon Attenuates Cognitive Dysfunction,Hippocampal Oxidative Stress and Neurodegeneration Following Status Epilepticus in Young Male Rats [J] . Mohammad Ahmad, Mohammad A.M.Wadaan 药剂与药理学：英文版 . 2021,第010期

2. Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus [J] . Dong-Qi Lin, Xin-Ying Cai, Chun-Hua Wang, 中国神经再生研究（英文版） . 2020,第005期

3. Mitochondrial and nuclear damages and caspase-3 expression in the hippicampal CA3 region of rats with kainic acid induced status epilepticus [J] . Shuhai Tang, Jianying Sun, Xiaojun Pan, 中国神经再生研究（英文版） . 2006,第007期

4. A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid [J] . Irene F. Ugidos, Diego Pérez-Rodríguez, Arsenio Fernández-López 中国神经再生研究（英文版） . 2017,第008期

5. Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus [J] . César Emmanuel Santana-Gómez, María Guadalupe Valle-Dorado, Ana Esmeralda Domínguez-Valentín, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2018,第期

6. Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy [J] . Neurotoxicology . 2012,第6期

7. Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus. [J] . Milhaud D, Rondouin G, Lerner Natoli M, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2003,第2期

8. Thalamic involvement of status epilepticus:diffusion-weighted image of MRI in two cases of status epilepticus [C] . Hiroshi Shigeto, Taira Uehara, Kazuki Uchida, International Evoked Potentials Symposium . 2005

9. Implementation and Evaluation of a Convulsive Status Epilepticus Protocol for Providers: An Evidence-Based Quality Improvement Project [D] . Tapp, Amanda C. 2020

10. Prospects of Levetiracetam as a Neuroprotective Drug Against Status Epilepticus Traumatic Brain Injury and Stroke [O] . Ashok K. Shetty 2013

11. Prospects of Levetiracetam as a Neuroprotective Drug against Status Epilepticus, Traumatic Brain Injury and Stroke [O] . Ashok K Shetty 2013

12. Dizocilpine (MK-801) Arrests Status Epilepticus and Prevents Brain Damage Inducedby Soman [R] . Sparenborg, S., Brennecke, L. H., Jaax, N. K., 1992

1. Neuroprotective agents effective against radiation damage of central nervous system [J] . Mária Lalkovičová . 中国神经再生研究:英文版 . 2022,第9期

2. 蛋白S缺乏引起上矢状窦血栓形成并发癫痫持续状态治疗一例 [C] . 石建国 ,付长怀 . 中华医学会急诊医学分会第17次全国急诊医学学术年会 . 2014

3. 芬戈莫德减轻大鼠弥漫性脑损伤炎症反应但加重脑损伤 [A] . 苏万强 . 2017