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METHODS FOR ACTIVATING RETROVIRUS IN LATENT INFECTED CELLS, AND COMPOUNDS FOR USE THEREIN
METHODS FOR ACTIVATING RETROVIRUS IN LATENT INFECTED CELLS, AND COMPOUNDS FOR USE THEREIN
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机译:在潜伏感染细胞中激活逆转录病毒的方法及其所用化合物
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摘要
The present invention relates to a method for increasing retrovirus transcription in an infected eukaryotic cell, comprising increasing Wnt pathway signaling in said cell such that transcription of said retrovirus is increased. Also, the present invention relates to a method of treating a subject infected with a retrovirus, said method comprising administering to said subject an activator of the Wnt pathway in an amount that increased Wnt pathway signaling in resting memory CD4+ T cells of said subject such that the retroviral long terminal repeat (LTR) in said cells is activated or de-repressed.
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