PROTOFIBRIL-BINDING ANTIBODIES AND USE THEREOF IN THERAPEUTIC AND DIAGNOSTIC METHODS FOR PARKINSON'S DISEASE, DEMENTIA WITH LEWY BODIES AND OTHER ALPHA-SYNUCLEINOPATHIES

摘要

FIELD: chemistry.SUBSTANCE: invention relates to biochemistry. Described are antibodies and fragments thereof, having high affinity for human ?-synuclein protofibrils and low binding of ?-synuclein monomers. Disclosed are compositions which contain the described antibody or a fragment thereof, methods of detecting ?-synuclein protofibrils using the described antibody or fragment thereof. In other versions, the present invention relates to methods of preventing, slowing down the development or treating a neurodegenerative disorder with ?-synuclein pathology, where said methods include administering the described antibody or fragment thereof. The invention also relates to use of said antibody or fragment thereof to obtain a pharmaceutical composition for treating a neurodegenerative disorder with ?-synuclein pathology.EFFECT: invention is used for diagnosis or monitoring of the development of a neurodegenerative disorder with ?-synuclein pathology, and in methods of reducing or inhibiting ?-synuclein aggregation by administering said antibody or fragment thereof.31 cl, 9 dwg, 4 tbl, 10 ex