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Glycomimetics as pseudomonas Aeruginosa lectin inhibitors

机译：糖代谢药作为铜绿假单胞菌凝集素抑制剂

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摘要

The present invention relates to fucose- and mannose-derived glycomimetics and their general use in prophylaxis or treatment of Pseudomonas aeruginosa infections including respiratory tract infections, urinary tract infections, nosocomial infections and chronic wound infections in a patient encompassing a patient suffering already from cystic fibrosis. Said glycomimetics are inhibitors of Pseudomonas aeruginosa lectin LecB.

机译：本发明涉及岩藻糖和甘露糖衍生的模拟物及其在预防或治疗铜绿假单胞菌感染（包括呼吸道感染，尿路感染，医院感染和慢性伤口感染）中的一般用途，所述患者包括已经患有囊性纤维化的患者。所述糖模拟物是铜绿假单胞菌凝集素LecB的抑制剂。

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公开/公告号EP2650289B1

专利类型
公开/公告日2016-07-27

原文格式PDF
申请/专利权人 UNIVERSITÄT KONSTANZ;
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申请/专利号EP20120002531
发明设计人 TITZ ALEXANDER DR.;
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申请日2012-04-10
分类号C07D309/10;A61K31/351;A61P31/04;
国家 EP
入库时间 2022-08-21 14:52:47

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2. Genomic Rearrangements and Functional Diversification of lecA and lecB Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa [J] . Amine M. Boukerb, Aude Decor, Sébastien Ribun, Frontiers in Microbiology . 2016,第6期

3. Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa [J] . Roman Sommer, Stefanie Wagner, Katharina Rox, Journal of the American Chemical Society . 2018,第7期

4. Discovery of two classes of potent glycomimetic inhibitors of pseudomonas aeruginosa LecB with distinct binding modes [J] . Hauck D., Joachim I., Frommeyer B., ACS Chemical Biology . 2013,第8期

5. Terminally modified Mannosides as high-affinity Inhibitors of Pseudomonas aeruginosa lectin lecb [C] . Hauck D., Frommeyer B., Furones B. International Carbohydrate Symposium . 2013

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7. Genomic Rearrangements and Functional Diversification of lecA and lecB Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa [O] . Amine M. Boukerb, Aude Decor, Sébastien Ribun, -1

8. Genomic rearrangements and functional diversification of lecA and lecB lectin-coding regions impacting the efficacy of glycomimetics directed against pseudomonas aeruginosa [O] . Boukerb, Amine M., Decor, Aude, Ribun, Sébastien, 2016

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