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Method for reducing effect of hematocrit on measurement of an analyte in whole blood
Method for reducing effect of hematocrit on measurement of an analyte in whole blood
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机译:减少血细胞比容对全血中分析物测量的影响的方法
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摘要
A method for determining the presence and/or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the hematocrit by reducing the size of the red blood cells. In optical detection systems, the smaller red blood cells create greater scatter, which allows a more accurate correction to be applied in a dual-wavelength detection system. In electrochemical detection systems, as well as in optical detection systems, the smaller red blood cells provide less obstruction to the diffusion of analyte and reagents in the sample, to facilitate the reactions thereof.
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