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BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY
BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY
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机译:骨形态发生蛋白2(BMP2)变种具有降低的BMP拮抗剂敏感性
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摘要
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
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机译:本发明涉及一种分离的肽,其包含氨基酸序列或由其组成,所述氨基酸序列与具有SEQ ID No.1的成熟人BMP2相比具有至少90%的氨基酸同一性,其特征在于,所述氨基酸序列包含至少两个氨基酸取代,其特征在于,第一氨基酸取代发生在对应于SEQ ID No.1的N59,S88,E94,V99,K101和/或N102及其用途的位置。
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