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MONITORING DIFFUSE LARGE B-CELL LYMPHOMA FROM PERIPHERAL BLOOD SAMPLES
MONITORING DIFFUSE LARGE B-CELL LYMPHOMA FROM PERIPHERAL BLOOD SAMPLES
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机译:从外周血样本中监测弥漫性大B细胞淋巴瘤
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摘要
The invention is directed to sequencing-based methods for monitoring a minimal residual disease of a diffuse large B cell lymphoma (DLBCL) by one or more clonotypes correlated with the disorder. In some embodiments, such methods comprise the following steps: (a) obtaining a sample of peripheral blood from the patient; (b) amplifying molecules of nucleic acid from the sample, the molecules of nucleic acid comprising recombined DNA sequences from immunoglobulin genes; (c) sequencing the amplified molecules of nucleic acid to form a clonotype profile; and (d) determining from the clonotype profile a presence, absence and/or level of one or more patient-specific clonotypes correlated with the DLBCL and phylogenic clonotypes thereof.
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