DEVELOPMENT OF pH-RESPONSIVE CYANINE-BASED NEAR-INFRARED DYE

摘要

PROBLEM TO BE SOLVED: To provide an objective compound that can give an image having good contrast, to provide an intermediate for the compound and to provide a contrast medium.;SOLUTION: The compound represented by formula (I) or a salt thereof is provided. (Z is O, S or NH; n₁ is 0, 1 or 2; Y is an alkyl group or (CH₂)n₂-CO-R^a; n₂ is an integer of 2 to 6; R^a is OH, alkoxy, NH₂ or NH(CH₂)₂-(OCH₂CH₂)_n-OR^b; R^b is H or an alkyl group; n is an integer of 2 or more; R is H, halogen, OH, alkoxy, alkyl, CN, NO₂ or carbamoyl);SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2016,JPO&INPIT