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Genome editing of the ROSA locus using zinc finger nuclease
Genome editing of the ROSA locus using zinc finger nuclease
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机译:使用锌指核酸酶编辑ROSA基因座的基因组
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摘要
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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