Its use in the efficient production of designer cell and enantiomerically enriched alcohol for the enantioselective reduction of ketones

摘要

present invention provides a variety of recombinant whole cell biocatalyst preparation called "designer cells" herein, wherein the cells are efficiency of various industrially important enantiomeric enrichment alcohol It has very enhanced carbonyl reductase activity for use in production. More specifically, the alcohol is optically pure ethyl to (S) -4- chloro-3-hydroxybutyrate, wherein the preparation of HMG -CoA (HMG-CoA) reductase inhibitors it is useful as a chiral building blocks and intermediates for.