Phosphodiesterase 5A inhibitor for the treatment of muscular dystrophy

摘要

Described herein are methods for treating muscular dystrophy, including Becker muscular dystrophy and Duchenne muscular dystrophy. The method comprises administering to a subject in need thereof a phosphodiesterase 5A (PDE5A) inhibitor such as tadalafil. Administration of the PDE5A inhibitor has beneficial effects such as recovery of functional sympathetic nerve blockade, reduction of ischemic invasion to dystrophin-deficient fascia, reduction of use-dependent muscle damage, Therefore, the progression of muscular dystrophy disease can be delayed.