首页>
外国专利>
Therapeutic and diagnostic applications based on the role of CXCR-4 gene in tumorigenesis
Therapeutic and diagnostic applications based on the role of CXCR-4 gene in tumorigenesis
展开▼
机译:基于CXCR-4基因在肿瘤发生中的作用的治疗和诊断应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXC R- 4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.
展开▼