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Method for producing compound having oxydifluoromethylene skeleton

机译:具有氧二氟亚甲基骨架的化合物的制备方法

摘要

An object of the present invention is to provide a method for producing a compound having an oxydifluoromethylene skeleton at a high yield by a simple process without using highly toxic starting materials, such as dibromodifluoromethane, while generating almost no difficult-to-separate impurities. A reaction between a thionocarboxylic acid ester (which may be obtained by a reaction between a halogenated thiocarbonyl compound and a specific compound as required) and a compound represented by Formula: XF n (wherein X represents chlorine, bromine, or iodine, and n represents a natural number of 1 to 5) gives a compound having an oxydifluoromethylene skeleton at a high yield. Various groups, such as an aromatic ring group, may also be introduced in high yield by reacting this compound with a boronic acid compound and the like as required.
机译:本发明的一个目的是提供一种通过简单的方法以高收率生产具有氧二氟亚甲基骨架的化合物的方法,而无需使用高毒性的起始原料,例如二溴二氟甲烷,同时几乎不产生难以分离的杂质。硫代羧酸酯(可以根据需要通过卤代硫代羰基化合物与特定化合物之间的反应获得)与下式表示的化合物之间的反应:XF n(其中X表示氯,溴或碘,n表示1至5的自然数)以高收率得到具有氧二氟亚甲基骨架的化合物。通过根据需要使该化合物与硼酸化合物等反应,也可以高收率地引入各种基团,例如芳族环基团。

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