Temperature-responsive chondrocyte-containing liquid preparation for cartilage tissue regeneration, production method and use thereof

摘要

PROBLEM TO BE SOLVED: To provide a cartilaginous tissue regeneration medial formulation capable of increasing phenotypic expressions of chondrocytes thereby suppressing inflammation of a recipient site.SOLUTION: In a temperature-responsive chondrocyte-containing fluid formulation, hyaluronic acid grafted to a polymer whose hydration force changes in the temperature range of 0-80°C is dissolved in saline, and 1×10pieces to 1×10pieces of cells are dispersed per ml of the formulation.