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Sense oligonucleotide capable of controlling the expression of INOS and composition comprising the same
Sense oligonucleotide capable of controlling the expression of INOS and composition comprising the same
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机译:能够控制INOS表达的有义寡核苷酸和包含该寡核苷酸的组合物
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摘要
The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
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