A clinical laboratory decision support system and method is disclosed that includes a medical knowledge database, a medical condition input, one or more user-selectable filters, a processor and an output device. The medical knowledge database includes medical tests and relevance information for each of the medical tests. The processor receives the medical condition and the user-selectable filters; accesses and searches the medical knowledge database for applicable tests; and sorts the applicable tests by relevance based on the medical condition, the user-selectable filters and the relevance information for each of the tests. The output device provides a sorted list of applicable tests by relevance as determined by the processor. A hospital interface can be for retrieving patient information, and the patient information can also be used in sorting the applicable tests by relevance. The sorted list of applicable tests can include payment and/or cost information, and visual indicators of relevance.
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