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System for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis

机译:无需水解即可分析I相和II相代谢物和母体化合物的系统

摘要

An apparatus comprises: a first chromatographic column fluidically coupled to a source of sample and a source of a first chromatographic mobile phase solvent; a second chromatographic column fluidically coupled to the first column; a source of a second mobile phase solvent fluidically coupled between the first and second columns; and a detector, the first chromatographic column being configurable to receive, in a trapping step, the first solvent and sample and to retain a first portion of a plurality of analytes therein and to pass a second portion of the plurality of analytes therethrough, the second chromatographic column being configurable, in the trapping step, to receive the second portion of the plurality of analytes and the first and second solvents and to retain the second portion of the plurality of analytes therein, the detector being arranged to receive the second and first portions in respective first and second elution steps.
机译:一种设备,包括:第一色谱柱,其流体耦合至样品源和第一色谱流动相溶剂的源;以及第二色谱柱,流体连接至第一色谱柱;在第一和第二塔之间流体耦合的第二流动相溶剂的源;以及检测器,第一色谱柱可配置为在捕获步骤中接收第一溶剂和样品,并在其中保留多种分析物的第一部分,并使多种分析物的第二部分从中通过,第二种色谱柱在捕获步骤中可配置为接收多种分析物的第二部分以及第一和第二溶剂,并将多种分析物的第二部分保留在其中,检测器布置为接收第二部分和第一部分在相应的第一和第二洗脱步骤中。

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