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Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease
Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease
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机译:抗ICOS抗体及其在肿瘤,移植和自身免疫性疾病治疗中的应用
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摘要
The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis (opsonization) for the treatment and prevention of T cell-mediated diseases and disorders, such as, but not limited to, chronic infection, autoimmune disease or disorder, inflammatory disease or disorder, graft-versus-host disease (GVHD), transplant rejection, and T cell proliferative disorder.
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