首页> 外国专利> Michigan inhibitor, nucleic acid molecule used for coding, expression vector, C? Lula hughesped unable to regenerate a plant or animal, processing method, including drug composition, method used for drug production, and method used for measuring near factors in samples

Michigan inhibitor, nucleic acid molecule used for coding, expression vector, C? Lula hughesped unable to regenerate a plant or animal, processing method, including drug composition, method used for drug production, and method used for measuring near factors in samples

机译:密歇根州抑制剂,用于编码的核酸分子,表达载体,C 1。卢拉拥抱无法再生动植物的方法,加工方法,包括药物成分,用于药物生产的方法以及用于测量样品中近因的方法

摘要

This application relates to binding agents comprising peptides which have the ability to bind and inhibit the activity of myostatin. In a form of realization, the binding agent comprises at least a myostatin Peptide Binder which is connected, directly or indirectly, to a vehicle, as a minimum, that can be a Polymer or an FC domain.The binding agents of the present application produced an increase in lean muscle mass when administered to Animals and reduce the relationship between fat and Muscle.Therapeutic compositions containing binding agents of this application are used to treat Disorders associated with muscular dystrophy and consumption, such as cachexia, like other Metabolic Disorders including Diabetes and obesity.
机译:本申请涉及包含具有结合和抑制肌生长抑制素活性的能力的肽的结合剂。在一种实现方式中,所述结合剂包括至少一个肌生长抑制素肽结合剂,其至少直接或间接地与可以是聚合物或FC结构域的媒介物连接。当向动物给药时,增加了瘦肌肉的质量并减少了脂肪与肌肉之间的关系。含有本申请结合剂的治疗性组合物可用于治疗与肌肉营养不良和食用相关的疾病,例如恶病质,如包括糖尿病和糖尿病在内的其他代谢性疾病。肥胖。

著录项

  • 公开/公告号AR097588A2

    专利类型

  • 公开/公告日2016-03-23

    原文格式PDF

  • 申请/专利权人 AMGEN INC.;

    申请/专利号AR2014P103349

  • 发明设计人 HAN HQ;MIN HOSUNG;BOONE THOMAS;

    申请日2014-09-08

  • 分类号C07K19;A61K38;A61K38/08;A61K38/10;A61K38/16;A61K38/17;A61K38/18;A61K47/48;A61P3;A61P3/04;A61P3/10;A61P11;A61P13/12;A61P19/02;A61P19/08;A61P21;A61P35;A61P37;C07K7/06;C07K7/08;C07K14;C07K14/475;C07K14/495;C12N1/21;C12N5/10;C12N15/11;C12N15/62;C12N15/63;C12Q;C12Q1;G01N33/53;

  • 国家 AR

  • 入库时间 2022-08-21 14:27:37

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