'Heat shock protein affinity polypeptide and its use in the diagnosis of infectious disease, immune response production and treatment of cancer, as well as nucleic acid, substance composition and fractionation method for clinical sample research or analysis.'

摘要

heat shock protein (hsps) affinity polypeptides and hsp associated complexes (hacs) and their use in diagnosis and therapy The present application is directed to peptides comprising an amino acid sequence of formation of 244 -helix that binds to a heat shock protein. Also included is a polypeptide comprising (a) a first peptide moiety comprising a Î ± -helix forming amino acid sequence that binds to heat shock proteins and (b) at least a second peptide moiety comprising a heat shock protein sequence. antigenic amino acids and / or a Î ± -helix stabilization amino acid sequence that enhances the interaction between the first peptide moiety and the heat shock protein. The present application also includes compositions comprising the petids and / or polypeptides of the present application and use of the peptides and / or polypeptides of the present application for fractionation of substances relevant for the discovery, screening or clinical analysis of a biological sample and as therapeutic agents.