nucleotide sequence, nucleotide construct, cell or cell line, method for fibrinogen production in a eukaryotic cell culture system, fibrinogen preparation, use of fibrinogen preparation, method for cell or cell line selection

摘要

The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.