pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration

摘要

"pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration, use thereof and a recombinant factor VII extinction derivative and method for treating hemophilia". The present invention relates to a pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration comprising coagulation factor viii or factor ix and its use for the manufacture of a medicament for treating hemophilia a or b. The formulation comprises a coagulation factor viii or factor ix, with an activity of at least 200 ui per ml, and an additive for increasing factor viii or factor ix bioavailability. factor viii tests give a therapeutic level of active factor viii in the bloodstream for a surprisingly long time following subcutaneous, intramuscular or intradermal administration. factor viii is suitably a highly purified recombinant factor viii and preferably a derivative thereof which may be used in the manufacture of a medicament for subcutaneous administration.