Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone

摘要

The present invention relates to an improved process for producing naltrexone [17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone [4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.