4-HYDRAZINO-6-PROPY1-1-PHENY1-1H-PYRAZOLO3,4-D PYRIMIDINE AS A POTENT ANTIASTHMATIC AGENT WITH POTENT AND SELECTIVE ADENOSINE A3 RECEPTOR ANTAGONISM

摘要

The present invention provides compound, PZ-P-HH and pharmaceutieally acceptable salts or prodrug thereof and methods for synthesizing PZ-P-HH and methods for adenosine receptor binding, antagonism, bronchodilation activity, treatment of asthma and COPD Provided are compound of the following structural formula Acknowledgements: The authors profusely thank Professor, Dr. Karl Norbert Klotz, Department of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Strasse 9, D-97078, Wuerzburg, Germany for Adenosine receptor binding and antagonistic studies with required funding to screen the title compound. We thank Mr. Rajashekar and Ms. Chandhana, Department of Pharmacology, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram - 534 202, W.G. Dist., AP, India for supporting in screening the above compound for antiasthmatic activity.