AN IMPROVED PROCESS FOR THE PREPARATION OF(4S)-1-METHYL-2- OXOIMIDAZOLIDINE-4-CARBOXYLIC ACID T BUTYL ESTER KEY INTERMEDIATE OF IMIDAPRIL

摘要

Abstract: The objective of the present invention is to provide an improved process for the preparation of Imidapril that avoids the use of high pressure hydrogenation and gaseous hydrogen under pressure. There is provided a process for the preparation of 1-methyl-2- oxoimidazolidine-4-carboxylate of formula (II), the said process comprising the step of deprotecting the amino protecting group in compound of formula (III), using a metal catalyst, hydrogen donor and in the presence of solvent to provide compound of formula (II) wherein PG and PG1 represents protecting groups.