Piridopirazolopirimidinonas (AZA) and indazolopirimidinonas as inhibitors of fibrinolysis

摘要

Refers to compounds (AZA) piridopirazolpirimidinonas and indazolpirimidinonas replaced formula (i-a), processes for their preparation for the treatment of acute Bleeding, such as menorrhagia, Myocardial, hepatic diseases, etc.Where R1 is H or alquiloc1 - C4; R2 is n or C - X1; x2 is n or C - R3; X3 is n or C - R4, R5 X4 is n or C, with the proviso that 0, 1 or 2 x1 to X4 are nitrogen; R2, R3, R4 and R5 are H, halogen, etc. with the exception that Zero, One. Two or three of R2 R5 H are different.Preferred compounds are: hydrochloride 4 - (piperidin-4-yl pirimido il) [1,2-b] - 2 - (1h indazol Ona hydrochloride hydrochloride; 4 - (piperidin-4-yl il) - 9 - (trifluoromethyl) pirimido [1,2-b] indazol - 2 (1H) - One, among others