N- (methyl) -pyridin-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid proteins

摘要

A compound having the general formula (IIa) or (IIb) ** Formula ** in which p is 2 or 3; each linker K is independently C1-3alkylene which is optionally substituted with one or more C1-4alkyl groups; heterocyclic ring B is optionally substituted with one or more substituents selected from C1-4alkyl, C1-4alkoxy, mono- and di-C1-4alkylamino, C3-7cycloalkylamino and 5- or 6-membered saturated heterocyclyl, or two substituents they can join to form a saturated, unsaturated or aromatic 5- to 7-membered ring that fuses with heterocyclic ring B; R1 is selected from -H, -halogen, -C1-4alkyl, NH2, -NH-C1-4alkyl, -C1-4alkylene-NH2, -C1-4alkylene-NH-C1-4alkyl, -aryl, -aryl-R3, -C1-4alkylenyryl, -C1-4alkylenylaryl-R3, -heteroaryl, heteroaryl-R3, -NH-C1-4-alkylenyl, -NH-C1-4-alkylenearyl, -OH and -O- C1-4alkyl; and R3 is C1-4alkyl, halogen, OH or O-C1-4alkyl; R2 is -H, -C1-4alkyl, -aryl or a group of the formulas (IIIa) or (IIIb) ** Formula ** where in the formulas (IIIa) and (IIIb): the heterocyclic ring B is optionally substituted with one or more substituents selected from C 1-4 alkyl, C 1-4 alkoxy, mono- and di-C 1-4 alkylamino, C 3-7 cycloalkylamino and saturated 5- or 6-membered heterocyclyl, or two substituents can join to form a ring saturated, unsaturated or aromatic of 5 to 7 members that is condensed with the heterocyclic ring B; each linker K is independently C1-3alkylene which is optionally substituted with one or more C1-4alkyl groups; R1 is selected from -H, -halogen, -C1-4alkyl, -NH2, -NH-C1-4alkyl, -C1-4alkylene-NH2, -C1-4alkylene-NH4-4alkyl, -aryl, - aryl-R3, -C1-4alkylenearyl, -C1-4alkylenearyl-R3, -heteroaryl, -heteroaryl-R3, -NH-C1-4alkylearyl, -NH-C1-4alkylenyl aryl, -OH and -O- C1-4alkyl; q is 0 or 1; and r is 0 or 1.