RESOLUTION OF (±)-METHYL PHENYL4-4-4'-(TRIFLUOROMETHYL)-2-BIPHENYLYLCARBONYLAMINOPHENYL-1-PIPERIDINYLACETATE

摘要

The present invention relates to a resolution process of (~)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP(microsomaltriglyceride transfer protein) inhibitor methyl(2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]-acetate and an epimerisation procedurefor racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.