Combination of anti-clusterin oligonucleotide with androgen receptor antagonist for the treatment of prostate cancer

摘要

A method for treating a mammalian subject afflicted with prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) an androgen receptor antagonist having the structure (I) or a pharmaceutically acceptable salt thereof, each in an amount that when in combination with the other is effective treat the mammalian subject.