BOUCHARDATINE AND BOUCHARDATINE DERIVATIVES, AND PREPARATION METHOD AND APPLICATION THEREFOR

摘要

Disclosed is an application of natural product bouchardatine and bouchardatine derivatives in the preparation of a drug combatting obesity and/or easing fatty liver generation. The structural formula of the bouchardatine derivatives is shown in formula (I), wherein: R is -(CH₂)_nR₁, n being 0, 1, 2 or 3; R₁ is selected from: (1) a phenyl group substituted with one or a plurality of R₂s; (2) a morpholino group or a piperidyl group; (3) an N,N-dimethylamino group or an N,N-diethylamino group; R₂ is a fluoro group, a methoxy group or a nitro group. The natural product and the derivatives thereof significantly inhibit the differentiation of 3T3-L1 preadipocytes and thereby reduce lipid accumulation within 3T3-L1 adipocytes, reduce the accumulation of lipids in human hepatoma cells caused by sodium oleate, and have the effects of reducing animal cell triglyceride levels, combatting obesity and easing fatty liver generation.