METHOD FOR DIRECTLY CONVERTING HUMAN FIBROBLASTS INTO NEURAL STEM CELLS USING SMALL MOLECULE COMPOUNDS

摘要

The present invention relates to a method for converting human fibroblasts into neural stem cells and, more specifically, to a method for directly converting human fibroblasts into neural stem cells using only a combination of small molecule compounds without an introduction of foreign genes; and a use thereof. The method according to the present invention for directly converting human fibroblasts into neural stem cells using only small molecule materials without gene introduction is useful for utilization in a cellular therapeutic agent of brain diseases, as it is possible to secure a sufficient amount of cells to be used in cell therapy through the induction of genetically stable neural stem cells, and to differentiate into various types of functional nerve cells, and tumors are not caused.