COMPOUND AND METHOD FOR VACCINATION AND IMMUNISATION

摘要

The present invention relates to the use of agents that enhance the effects of sensitizing agents, antigen molecules, such as vaccine components and photochemical internalization (PCI) -mediated vaccination, and irradiation with light of wavelengths effective to activate the sensitizing agonist , Wherein the agonist is a ligand for a toll-like receptor (TLR) as defined herein. The invention also relates to antigens useful in such methods, e. G., Vaccine compositions. The present invention also relates to a method for producing an immune response comprising the step of introducing an antigen molecule, e. G., A vaccine component into a cell, using the same components as above to achieve antigen presentation, Lt; RTI ID = 0.0 and / or / RTI antigenic compositions useful in such methods. The invention also provides the use of cells generated in vitro by such methods for inducing an immune response, for example, for administration to a patient in vivo to achieve a vaccination. Methods of internalizing antigen molecules into cells are also provided.