Method of drug loading in cell-derived membrane vesicles by engineering parent cells with membrane fusogenic liposomes and drug delivery method using thereof

摘要

The present invention relates to a cell membrane vesicle encapsulated with a drug prepared using membrane fusogenic liposome (MFL), a method for producing the cell membrane vesicle and a drug delivery method using the cell membrane vesicle, , The cell membrane vesicle of the present invention can simultaneously encapsulate a hydrophilic drug and a hydrophobic drug, and it is a cell membrane vesicle isolated from a cell, so as to enable more efficient and selective drug delivery to peripheral cells, Because of the safety of the material and the step of enclosing the drug directly in the cell membrane vesicle, there is no need for the cell membrane vesicle to be useful for the prevention and treatment of various cancer and degenerative diseases known to play an important role in cell membrane vesicles.