TALEN GRK5 METHOD FOR PREPARING GRK5 KNOCKOUT MOUSE USING TALEN

摘要

The present invention relates to a method for easily and efficiently producing GRK5 knockout transgenic mice using a transcription activator-like effector nuclease (TALEN), wherein the transgenic mice produced by the method of the present invention are useful for the treatment of Alzheimer's disease Can be used as an animal model for studying causes and pathogenic mechanisms and for developing new drugs.